Chapter 1, "Columbus, the Indians, and Human Progress" covers early Native American civilization in North America and the Bahamas, the genocide and slavery committed by the crew of Christopher Columbus, and the violent colonization by early settlers. Topics include the Arawaks, Bartolomé de las Casas, the Aztecs, Hernando Cortes, Pizarro, Powhatan, the Pequot, the Narragansett, Metacom, King Philip's War, and the Iroquois.Chapter 2, "Drawing the Color Line" addresses early slavery of African Americans and servitude of poor British people in the Thirteen Colonies. Zinn writes of the methods by which racism was artificially created in order to enforce the economic system.

He argues that racism is not natural because there are recorded instances of camaraderie and cooperation between black slaves and white servants in escaping from and in opposing their subjugation.Chapter 3, "Persons of Mean and Vile Condition" describes Bacon's Rebellion, the economic conditions of the poor in the colonies, and opposition to their poverty.Chapter 4, "Tyranny is Tyranny" covers the movement for "leveling" (economic equality) in the colonies and the causes of the American Revolution. Zinn argues that the Founding Fathers agitated for war to distract the people from their own economic problems and stop popular movements, a strategy that he claims the country's leaders would continue to use in the future.Chapter 5, "A Kind of Revolution" covers the war and resistance to participating in war, the effects on the Native American people, and the continued inequalities in the new United States.

When the land of veterans of the Revolutionary War was seized for non-payment of taxes, it led to instances of resistance to the government, as in the case of Shays' Rebellion. Zinn wrote that "governments - including the government of the United States - are not neutral...

they represent the dominant economic interests, and... their constitutions are intended to serve these interests."[4]Chapter 6, "The Intimately Oppressed" describes resistance to inequalities in the lives of women in the early years of the U.S.

Zinn tells the stories of women who resisted the status quo, including Polly Baker, Anne Hutchinson, Mary Dyer, Amelia Bloomer, Catharine Beecher, Emma Willard, Harriot Hunt, Elizabeth Blackwell, Lucy Stone, Elizabeth Cady Stanton, Margaret Fuller, Sarah Grimké, Angelina Grimké, Dorothea Dix, Frances Wright, Lucretia Mott, and Sojourner Truth.Chapter 7, "As Long As Grass Grows or Water Runs" discusses 19th Century conflicts between the U.S. government and Native Americans (such as the Seminole Wars) and Indian removal, especially that done by the administrations of Andrew Jackson and Martin Van Buren.

Chapter 8, "We Take Nothing By Conquest, Thank God" describes the Mexican-American War. Zinn writes that President James Polk agitated for war for the purpose of expansionism. Citing evidence, Zinn states that the war was unpopular but that newspapers of that era misrepresented the popular sentiment.Chapter 9, "Slavery Without Submission, Emancipation Without Freedom" addresses slave rebellions, the abolition movement, the Civil War, and the effect of these events on African-Americans.

Zinn writes that the large-scale violence of the war was used to end slavery instead of the small-scale violence of the rebellions because the latter may have expanded beyond anti-slavery, resulting in a movement against the capitalist system. He writes that the war could limit the freedom granted to African-Americans by allowing the government control over how that freedom was gained.Chapter 10, "The Other Civil War", covers the Anti-Rent movement, the Dorr Rebellion, the Flour Riot of 1837, the Molly Maguires, the rise of labor unions, the Lowell girls movement, and other class struggles centered around the various depressions of the 19th Century. He describes the abuse of government power by corporations and the efforts by workers to resist those abuses. Here is an excerpt on the subject of the Great Railroad Strike of 1877. [1][5]Chapter 11, "Robber Barons and Rebels" covers the rise of industrial corporations such as the railroads and banks and their transformation into the nation's dominant institutions, with corruption resulting in both industry and government.

Also covered are the popular movements and individuals that opposed corruption, such as the Knights of Labor, Edward Bellamy, the Socialist Labor Party, the Haymarket martyrs, the Homestead strikers, Alexander Berkman, Emma Goldman, Eugene V. Debs, the American Railway Union, the Farmers' Alliance, and the Populist Party.